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18.12.25, غϼ2522018.12.6-10

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һƪΪѧνʱЪѧڹʵҺ
ģΪͨѶߣGuofa LiuΪһߡ

J Neurosci. 2007 Jan 24; 27(4): 957C968.
p130CAS Is Required for Netrin Signaling and Commissural Axon 
Guidance
Guofa Liu, Weiquan Li, Xue Gao,1,2 Xiaoling Li,1 Claudia Jrgensen, 
Hwan-Tae Park, Nah-Young Shin, Jian Yu, Ming-Liang He, Steven K. Hanks, 
Jane Y Wu, Kun-Liang Guan, and Yi Rao1

Fig.2d3е12Fig.2e2еֻͬȲͬ
ڲͬͼƬʾͬһʵ١

Fig.2hĵ1е2͵6ͬ4͵5ͬⶼǲ
ͬʵʾͬһʵĽ١

ڶƪΪʥ·˹ĻʢٴѧνʱģΪͨѶ
ߣGuofa Liu,Hilary Beggs,Claudia Jrgensen,Hwan-Tae ParkΪͬһ
ߡ

Nat Neurosci. 2004 Nov; 7(11): 1222C1232.
Netrin requires focal adhesion kinase and Src family kinases for 
axon outgrowth and attraction
Guofa Liu,Hilary Beggs,Claudia Jrgensen,Hwan-Tae Park,Hao 
Tang,Jessica Gorski,Kevin R Jones,Louis F Reichardt,Jane Wu,and Yi Rao

Fig.1jһеFig.2cһеͬڲͬͼƬ
ʾͬһʵ١

Fig.3dһFig.3eһͬڲͬͼƬʾͬһʵ
١

ƪΪѧνʱЪѧڹʵҺ
ģWeiquan LiΪͨѶߣWeiquan LiΪһߡ

J Cell Sci. 2006 Jan 1; 119(Pt 1): 47C55.
FAK and Src kinases are required for netrin-induced tyrosine 
phosphorylation of UNC5
Weiquan Li, Jennifer Aurandt, Claudia Jrgense, Yi Rao, and 
Kun-Liang Guan

Fig.1B1е12ͬʵͬ١

Fig.1B2е12ͬ34ͬ56ͬ
ʵͬ١

Fig.2D3е36ͬ47ͬ58ͬʵ
ͬ١

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١

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ƪαѧʱѧJane WuЪѧ
ڹʵҺģ㡢Jane WuΪͬͨѶߣGuofa 
Liu, Weiquan LiΪͬһߡ

Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8): 2951C2956.
DSCAM functions as a netrin receptor in commissural axon 
pathfinding
Guofa Liu,Weiquan Li,Lei Wang,Amar Kar,Kun-Liang Guan,Yi Rao,and 
Jane Y. Wua

Fig.2D1е12ͬʵͬ١

5ƪʥ·˹ĻʢٴѧνʱЪѧڹ
ʵҺģΪͨѶߣWeiquan LiΪһߡ

Nat Neurosci. 2004 Nov; 7(11): 1213C1221.
Published online 2004 Oct 17. doi: 10.1038/nn1329
Activation of FAK and Src are receptor-proximal events required 
for netrin signaling
Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, 
Jennifer Aurandt, Tang-Long Shen, Eric R Fearon, Jun-Lin Guan, Min Han, 
Yi Rao, Kyonsoo Hong, and Kun-Liang Guan

Fig.1a4е12ͬʵͬ١

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2018.12.24.

(XYS20181225)

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1
J Neurosci. 2007 Jan 24; 27(4): 957C968.
p130CAS Is Required for Netrin Signaling and Commissural Axon 
Guidance
Guofa Liu, Weiquan Li, Xue Gao,1,2 Xiaoling Li,1 Claudia Jrgensen, 
Hwan-Tae Park, Nah-Young Shin, Jian Yu, Ming-Liang He, Steven K. Hanks, 
Jane Y Wu, Kun-Liang Guan, and Yi Rao1

2
Nat Neurosci. 2004 Nov; 7(11): 1222C1232.
Netrin requires focal adhesion kinase and Src family kinases for 
axon outgrowth and attraction
Guofa Liu,Hilary Beggs,Claudia Jrgensen,Hwan-Tae Park,Hao 
Tang,Jessica Gorski,Kevin R Jones,Louis F Reichardt,Jane Wu,and Yi Rao

ָ1Fig.2d2eظͼƬ2طظͼ
ƬظԭΪͬһʵ飬١Ϊ˾󾫣͹
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ߵٻƪƵͼƬ٣

J Biol Chem. 2004 Sep 3;279(36):37398-406
Transformation potential of Ras isoforms correlates with 
activation of phosphatidylinositol 3-kinase but not ERK
Weiquan Li , Tianqing Zhu , Kun-Liang Guan

Fig.3D2е25710ȫֻͬǰȫ̸
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J Biol Chem. 2001 Sep 14;276(37):34728-37.
Function of the Rho family GTPases in Ras-stimulated Raf 
activation
Weiquan Li , Huira Chong , Kun-Liang Guan

Fig.2A1е3456ȫͬô޼ɵ

J Biol Chem. 2004 Jul 30;279(31):32824-31.
The Down syndrome cell adhesion molecule (DSCAM) interacts with 
and activates Pak
Weiquan Li , Kun-Liang Gua

    Fig.5C3е23ͬô޼ɵѱ壬
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2018.12.25.

(XYS20181225)

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ôĿ֮һǿСһѧʱҲã2009
ǰÿλһݷʱƺŭ̸ǣһԴԬ
үȡ2004ѧֱ֮2013ǳٽѧ
֮ǰûٸѧ棬ൺл
һоҶѧ档

2013ǳѧ棬˵ҪͻԺʿȥҰʱ
ʼһ¥ѧȷȽ磬һЩ˸
ȻһҲΪʱǳٲڳĶҲʶС
еֻԾһա˵ڵҴһѧ/о
ĺ¥ŴһоĺʵҷʹWHOI
ӢPML¹BSHͺKORDIȵЩһĺоԱȷ
λѧѾһҪһ㣬Ѿ
һ˵ǲӲһˣĻҲˡ
ѧձǰɣǸͱȽͳҪϽ
38֮СŸԬСѧ϶Ǹ
9֮ǴҽĿǡһɹоо
ѾͶˣ˷major revision
ͿԷǣԼݴϴϵͳų
֮ڲ֧ͬµķ֣˾major revision
εĸ塣Ϊһɹоľ飬ҽ˵ʱҺͺ
ζԽе˷ܣηַģܽһо
ĳҪǶȼ֤ĹǳٽˣΪץסо
Բ˵İѱͱ˵طʣһݺաû뵽ǰ
ǽһɹİǽڿ϶ԼѧΣյġ
ǲǵ2014Ҫŭ̯Ƶԭ֮һ޷ȷϡ

2014ԿԬԺʿļȺںңҺ
ҽͬġңҿѧ߻ڰŪʮ
ǰԬԺʿνSARӰ̽⺣׵εĻơҲ֪ǹ
Ϊ˳Ƕǰ˵ķ⣬Ҿ˭ķ
лʱҪ֤ԺʿۺͷҪԴë˼һ
ʵзңҺңҵıĿǡƼĽ
ڹǱ򡱡Ҫ̸Լľʶ˵ȥ֮ǰû
κ۹ĽṹϺͷƣݡ
ɡۡǰҪЩۡ˵ȥ֮ſ֮ͬǳ
ۣʶĵĽṹƺܼ򵥣ʵĹʦ
ĸʽÿһֲһ£ṹҪӦص

20132014ںһԬԺʿڳ
оڳǲǵԬԺʿȺ֣ȫͻԺʿ
ŭ̯Ƶԭ޷ȷϡܹȷǣ
ûԬԺʿǳ˵ǣ2004Ҵ֮
ѾԬԺʿ󲿷Ժʿһһѧ٣ѧ
СŶѣǵѧˮƽ͵²غõҲг
黳ľͲм˵ˡЩҲǲȷʶҴδڹ
˽˳϶ûб¶ӹɣѡ뿪һȥŴѧ
ڿ͹ϾǶԬԺʿӪѧУЩ͹ì
޷رܵġ20132014ںһԬԺʿ
ȥΪڡָ㽭ɽ̨Ҷ⣬ʱ
ûгȥĹ⡣֣ȫңһ˵ǷĹõ˴
֤˵ҷ˼ҵĹûиݵģһ˵
ܲҳһ۵硣

2014ԬԺʿŭض˵Ҫָ㽭ɽָ̫ˣȻ
ָָŰ칫ſڣʾҹȥҷˡǷ⡱
ɹרҵXYS20140923ָν⡱ĳɹʵһ
ѧǷѧɾ͡XYS20170728
͡Ƿ˶䡰ˮƽĳɾ͡XYS20171011ĵϵ
¶ѾԬҵԺʿǳѧƱɶ˵ˡϣ
ѧ˿ԬҵԺʿδӺ̨ǰ̨ģʲô̼
ӽ

(XYS20181225)

˿(www.xys.org)(newxys.com)(xys10.dxiong.com)

ٱϾѧѧѧԺѧ߻Ӵѧ

ߣJovisii

ֵÿһιϾѧѧ߻Ӵѧ˵ʱˡ

1. Zhang Xiaoxin et al. 2015. Salmonella VNP20009-mediated RNA
interference of ABCB5 moderated chemoresistance of melanoma stem cell
and suppressed
tumor growth more potently. Oncotarget 7: 14940. л12¡

2. ⣬˻ޱӴ 2016. ɳϾ VNP20009 
ü΢Ӱ졣ҩѧѧ 51 1417-1422

һƪFig. 5ĵһ=ڶƪFig. 3A.

滹У~

(XYS20181225)

˿(www.xys.org)(newxys.com)(xys10.dxiong.com)

ǿߡ˽˾ȷ췽

ߣϪ
Դ

壬մݺƽHennepinˡMike 
Freemanַйǿϡ

һʱ䣬һΪǿüģߵǿ
жԼ췽ʾʧģΪǿ췽ʧ

ʵⶼƫġҲ˽һɵԶ
ȷƽٵе

ͼ췽߱׼вͬ

ȣĴΪٵǷֱģٷ
˾šҲǼƽ⣨checks and balancesһڣ
ԱְܾȨ֮һáԣһᱻ
ߡһǸֳξǷҪһˣ
һױ׼Ƿϡ

··ƶȡԣ񣬲Ǿ
˵㣬ҲǼ˵㣬Ųþ;˾
ߵ𣺾ֻҪԼ˷ˣͻٱ
˷ˣ߲塣

ȻһѡִĹңԼٿѡЩӼ
ȥԷϣЩȻٲǿ
Ա塢Ϊ׼ѡΪЩ
ܵɱκηʽΪҲԵĿΪѡ׼
УΪθܡ

Ƿһӣһ˵ٻῼ¼档

1û㹻֤ݡû㹻֤ݣ߸޴̸

Ѿ˵ٵ˷ˡֻǼ
ûá

ԭǽٽй֪һ˵ǣɷŹһ
ǧҲһҪҪܶвٴ

Ҫ󣬼췽֤ų˺Ļɣproven 
beyond a reasonable doubtһȽϸߵżų
ɡҪˣŹ12ԱֻҪһ˲ϿɣͲܶ
ԣû㹻˶кɣǾͲԸ
ϡ

2û㹻ԴѡִҪԭԴ
ޡѡִͿ԰޵ҪĵطԵӾ׷
˰ͬȥһ˵ı˰Ȳ˵ı˰϶
ͬ·ڶΰӰķΪϲЧ

3Ƿ״η״ηһ棬ô
ԭ¹߷

4ܺǷԸվ֤һйϵܺ˲
Ըվ֤Ͳ˵Ŷ

5ǷԸ˿ṩ֤ץ㣬Ҳ
ῼԲΪ

ɴ˿ɼٶǷ
˵ߣ˵ӷֿܣһ
ΪӷһΪΪ˵5ԭѡ
ߡȻķǣûбͼ޹Ǽ޹
ʵ޹һ仰˵ǲܼ

˽ɵν췽˻
ȫķ룬Ӣȫĸ

ָйַ

ƽˡMike Freeman
йǿϡ

ᰢ˹MinneapolisԷﲿŵĳ׵
ַٵϸ飬óĽǣð֤ݷ⡣
ʹκָҪ֤ų˺ɣܡ

ַ¼һðθӣ˵Ҳ
ƵǣӷΪķ˫Ըġ¼
ţƵ֤˳ʶǲ
֤Σ޷ָءΪǲŮٴܵ˺
ǲ̸κΣ飩ϸڡ

֮ǰڱϱͶմѧɭѧԺ
Carlson School of Management45ǿʱᰢ˹
830գѺͬȥһUptownԷһ21ŮѧҲ
μ硣

Ůһͬǰִһӣ
ڵЩʱһͬѧĹԢСʱ831賿
ŮӵͬѧѴ绰ԱŮڹԢ
Լǿ̸˻ǵŮõϢԱ
绰ĴǣĳͻùݡЩʱմѧ

ӺһŮӲ˼ٵ֤飬ڼ䷢ֲĶԻ
ͶţǶӢġ֤ݰԾ¼
ΪŮڹԢڵ̸ͻù֮ǰŮ
˵̸̸һҲ¼档

Щ̸ݺ֤ݣλŮӺ˵֤ʣԼԶ
¼񣬶ָ֧ðָء

ƽٰ칫ʱðַ
˵ģرû˱¡һе
޹ءڵɺ漰ܺߵĸҥԶԿٰ칫ҵľҲû
Ӱ졣

ƽٰ칫Һͺƽٸһۡ

Լ췽Ľͺչ

ݼ췽ӾǱ׼ĵһ췽ߵԭû
֤ݡ

ǣǿԴһˣΪᱻ

ǣܻܿϡһ漰ֻ⳥
ǿ˵㲻ʲô

ƽٰ칫Ӣȫ

No sexual assault charges against Chinese businessman

No charges will be filed against Chinese businessman Liu Qiangdong 
for an alleged sexual assault, Hennepin County Attorney Mike Freeman 
announced Friday.

After a thorough investigation by the Minneapolis Police 
Department sex crimes unit and a meticulous review by four senior, 
sexual assault prosecutors, it was determined there were profound 
evidentiary problems which would have made it highly unlikely that any 
criminal charge could be proven beyond a reasonable doubt.

As is the case in many sexual assault incidents, it was a 
complicated situation, Freeman said. It is also similar to other 
sexual assault cases with the suspect maintaining the sex was 
consensual. As we reviewed surveillance video, text messages, police 
body camera video and witness statements, it became clear that we 
could not meet our burden of proof and, therefore, we could not bring 
charges. Because we do not want to re-victimize the young woman, we 
will not be going into detail.

As has been previously reported in the press, Liu, 45, was in 
Minneapolis as part of a program at the University of Minnesotas 
Carlson School of Management. On Aug. 30, he and a large number of 
friends and associates went to dinner at an Uptown restaurant. One of 
the people invited to the dinner was a 21-year-old female student. 

After dinner, the woman rode with Liu and others to a home on 
Franklin Avenue and eventually to her apartment near the university 
later that evening. After several hours, in the early morning of Aug. 
31, a fellow student and friend of the womans, called the police. 
Officers arrived at the womans apartment where they spoke to her and 
to Liu. Based on the information they learned from the woman that night, 
officers ended the call and took Liu back to his hotel. Liu was 
arrested later that day at the University of Minnesota. 

During the review of the evidence by the prosecutors, which 
consisted of three men and one woman, it was discovered that portions 
of the evidence included conversations and messages in Mandarin that 
were translated to English. That evidence included video from a body 
camera worn by the officers that captured conversations between Liu 
and the woman inside her apartment, and later, portions of the 
conversation between the two of them after the woman asked to speak 
privately with Liu before he was transported back to his hotel. 

The substance of those conversations, along with all of the other 
evidence including statements from the woman and others, as well as 
footage from multiple surveillance cameras, do not support criminal 
charges in this case. 

The three months it took for the Hennepin County Attorneys 
Office to review the case and make a decision is not unusual for a 
sexual assault case, especially one in which no one is in custody. It 
had nothing to do with Lius status as a wealthy, foreign businessman. 
Nor did the county attorneys office consider rumors involving Liu or 
the victim after the investigation was complete.

The Hennepin County Attorneys Office and Hennepin County 
Attorney Freeman will not be commenting further.

(XYS20181225)

˿(www.xys.org)(newxys.com)(xys10.dxiong.com)

غϼ2522018.12.6-10

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ŦԼԺ״ιָشշڸԺı¼˵
Ϊͳĸ1ָʹƶ1ȾŮ˷ڷѣԸѡ١
ƶָʹĴյȻҲΪͳûߣ̨
û˾׷ھͻᱻߡ
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ţзǽͨ˾ʷϴͳ
ڴ֮ǰֻпֶһǹ˾߷Ժģ˾
참ָĹ涨ͳߡͨ˵ͳ߹٣Ӧ
Ǵ紩ԽΪϹơġ 
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ǽͨԺ߷ԺʡԺˡɵ
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ʥڻأھѾõôûˡ
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£ҽ10ġҽϡΣ
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ܰ19.9ԪЬ129ԪļۣĻ黳Ь
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Ůʿй߱ҲʵָΪ˵
û令ղܱ֤Ϊʲôܶһ˽߹ڹӽ
թߣͦйˡĸ߶ȣ⡱
Ǻܰɣ
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ä
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ڻյ⣬Ϣ֣Լ3һ֤ڵ
ʹ뾳ʱҸº⣬1͵ûһգ
ŮʿΪΪ߹ܣÿ껻һն


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ۻգõŵڶۻ뾳˵ղ
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ܱͿռٱˡ//@Įӥ169916245
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۷ѧҲ㲻Ϊʲôһ˿ۻգ
Ч
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chun yung
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Foտ쵽ҪQIoգFoδںCpCȣ
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ŦԼͥϯִRoanne L. MannǩģͳҲ
ˣҴʹҪʲôã۶ںҪ˵
ۡ
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X Huan
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˽˾ƶȣڵ¹Ǽ췽ȨޣɵִУ
ߺ뷨ɳ򡣷ٽϰζʲôʣ


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вһɼ췽򾯷룬ɷٻΰǩûов
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ڷιҷͥǶġôʩѹûõġ
پ
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Lincoln Wang
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ͳܲ˾참ָָֻ
Ĺ˾׷Ҫĳҹ˾һ档ͳܵ˰참
վͲ˾ĵȴ޿κˡ


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ʱûвȥַȨǿ
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ץ˺Ͱѹ쵼ץˣ˵ǻΪ˭


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¡佺ʲôá
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ǰ־ֳ׽ڹ֤˵رղֹԴ
ͨĵ飬Ҫֺ˾˶˲Сʵʹ
սҲֹٵı¼Ȼʱ
زͿڣ˷ǰ׹Ʋ˵ģʱԽܡ
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˼Ա鱨ίԱϯ͸˹̨͵Ա
Ϊ̨Ϊָʹƶڷѵ±˾ߣܿΡ
ʶˣ
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׹Ļųｫ״ְ˹ͳĻųҮ˹Σ
ݺˣһʣҮ˹˵Ҳְ֪ڴ¸û
¡
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ԼѺӷǹͲ̫ܣֻǡ֪ʿ
⡱ûеڶ˿ҴɡˣӷͼôͲ
ơȨˣѵйӷʹͣ
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ôͳ˴񡱵ġȨֽ
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ֻɻһЧա˵ͬʱӵЧռȲҲ
Ӧ÷
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ǰر־ֳǰȫЭίԱ־ƽΪйԴ
ڷ޵ķչҪлߣȥŦԼڱŦԼٵ
Ժо7߿65꣨3̣Ϊʲô£
ΪлߵǮͨŦԼлġû˿ץˡ
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껪ΪӢضͨ˾˴Լ100ԪĲƷȻ
㵹ΪǺ׵ģֹڼɡ
ͨץ˸㻪ΪǱ취ҲɿأΪҪŶ
ԡʢʱǸרҵ˼άйͨһȡ
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ûΪƨɶԴ˼

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ֹɱһǧ˰˰ٵЩ˾ץԷ
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ձǿ±͸¶ܺŮǸгɾ͵ĸ
֡21꣬ûΪˣѱ쵽ָΪ
ͲϤ˾ѧУԱ̸ٴα췽ڽھ
Ƿߡʦָ֤ݣ类ԤƽԡԸΪɱ绤
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 Dec 10
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˭ڼôǷѺӦôͥ
habeas corpusپͻͥ˾ѺǷ
ǷͷšȥǷѺûõģ߲֪
£йûʵǡǷѺ
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habeas corpusԵĸ׼ȷ˵ǡѺ,Ҳûо
ɳץˣضץˣҲǡʧ١
Ҫ˴һﾳеġǷѺĲǳ򣬶ǡ



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ҲһΪѺܶѱ̵Ķ



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Ǹй˼ô˾ǰô⽻߹ʡ̫ѧ
ǡƭӡ⻹һƭӡŦԼʱפߣ5000θ»
ô˾󲿷йǲ֪С˾
ģΪйûйŵбµ˻ᡰˡ
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z^r
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㣬캰ν˾Σһ
Ĵ󷨹ôģ󷨹ٵĲһҪͳҪԺ
ͨûж˾أ󷨹ҲѲ
ɣ


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֤лȥʾͥר˿ӡҹ˾
ء
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Jason Li
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@JasonLi26294084
 Dec 10
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ǰǉKУŕGڠˣʾҲ֪ȥǉK
ЦpD]гFڬF


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¸绪ǱýJesse WinterֳƬȻpͼ

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Ц@˾ץ ֪ûʲô ƾʲôɲ
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ǰ֪ǲ֪ġ㵱ȻԺʺǰǲҪ
߿ƼƷڵʱ֤ʣҪƭûΥѸ߿
ƷʣΪܵõ㡣ץץ˭Ǽ췽ľ
㽻ͨΥܸ˵ôΥƾʲôץңû׵ġ


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¡ҿŵɴ
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 Dec 10
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ȡ֤û֤꣬һ⣬ƺʱ
ʦϵɷǲǼôʦ˵֪緹ͥͥ
ʦ˵ˣǰǼôڲˡٺܲȡ˵
дžܵˣΪʲôǾȴҪˣ
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 Dec 10
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ΪʲôͨڸƻȨΪרû룬Ϊ
йԺȶԺģ
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 Dec 10
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ЩרڳıߵʱЩԱڿʱܲȰָ
صָصĲǡΥ˷ǽթƭ
ӪҵСթڼôǲ
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 Dec 10
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ʦʷרҶӷҲϡͿġȡ֤۵Ǳ
뾳ĿܣȻȥ۷֤ݡ֤Ҳ
֤ݵǿ֮н׶ε¡ָصǽթ
֤ⷽݾ͹ˡ
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 Dec 10
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㻹ֻ˵ҪôϽԱݣҪõըô
Щѣǧ÷ٿ
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